Zyban (Bupropion): Complete Usage Guide (2025 Evidence-Based Review)
Zyban (generic name Bupropion SR) is an FDA-approved prescription medication that helps people quit smoking by reducing cravings and stabilizing mood. Although originally developed as an antidepressant, Zyban has been used for over 20 years as a proven smoking cessation aid. In 2025, Zyban remains a recommended first-line quit-smoking medication, especially for people who struggle with mood changes, stress, or withdrawal symptoms when quitting. This guide explains how Zyban works, proper dosage, benefits, side effects, precautions, and how to use it effectively. What Is Zyban (Bupropion SR)? Zyban is a non-nicotine medication that works on the brain chemicals dopamine and norepinephrine — two neurotransmitters strongly involved in nicotine addiction, motivation, and mood. Zyban does NOT contain nicotine and does NOT work like nicotine replacement therapy.Instead, it modifies the brain’s response…

